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產品描述
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A murine monoclonal antibody to an epitope on the globular head domain of C1q.
This monoclonal antibody was raised against purified human C1q Protein. It is specific for the globular head domain.
Quidel's C1q monoclonal antibody has been used in a variety of experimental techniques including EIA, Western Blot, Flow Cytometry, RIA, Hemagglutination and Immunohistochemistry.
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背景
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Circulating C1q protein is a hexamer of three unique protein subunits (A,B, and C) with molecular weights of 29, 26 and 22 kD respectively. The assembled hexamer contains a central core or stalk,six collagen-like domains and six globular protein heads. These globular or terminal regions are responsible for the binding of immunoglobulin (IgM,and IgG). As part of the C1 complex (together with two copies each of C1r and C1s) C1q is central to activation of the classical complement pathway
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參考資料
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1.Gershov D, Kim S.J., Brot N., Elkon K.B., “CReactive Protein Binds to Apoptotic Cells, Protects the Cells from Assembly of the Terminal Complement Components, and Sustains Antiinflammatory Innate Immune Response: Implications for Systemic Autoimmunity” J Exp Med 192(9), 2000.
2. Rogers J, Cooper N.R., Webster S, Schultz J, McGeer P.L., Styren S.D., Civin W.H., Brachova L, Bradt B, Ward P, Lieberburg I, “Complement Activation By b-amyloid in Alzheimer Disease” Proc Natl Acad Sci 89:10016-20, 1992.
3. Jack D.L.,Dodds A.W.,Anwar N, Ison C.A., Law A, Frosch M, Turner M.W., Klein N.J., “Activation of Complement by Mannose-Binding Lectin on Isogenic Mutants of Neisseria meningitides Serogroup B1” J Immunol 160:1346-53, 1998.
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