A p38 MAP kinase inhibitor. VX-702 dose-dependently inhibited the production of IL-6, IL-1 and TNF (IC= 59, 122 and 99 ng/ml, respectively). Pre-incubation of platelets with VX-702 (1 M) completely or partially inhibited platelet agonist induced p38 activation (IC= 4 to 20 nM).